Brentwood is a city in Contra Costa County, United States. It is located in the East Bay region of the San Francisco Bay Area; the population is 51,481 as of 2010, an increase of 121 percent from 23,302 at the 2000 census. Brentwood began as a community in the late 19th century, is still known throughout the Bay Area for its agricultural products its cherries and peaches. Due to urban sprawl many of the old farms and orchards have been replaced by suburban developments since 1990. Brentwood is residential, with the rate of population growth in the triple digits during the 1990s and 69% from 2000 through 2010. An official estimate showed the population increased nearly 21% during the period 2010 to 2016. Brentwood was laid out on land donated from property owned by John Marsh, an East Contra Costa County pioneer who acquired Rancho Los Meganos, the land grant that Brentwood is built upon, in 1837 from Jose Noriega. Marsh was one of the wealthiest men in California and was instrumental in its becoming independent from Mexico and part of the United States.
His letters extolling the potential for agriculture in California were published in newspapers throughout the East. They resulted in the first wagon trains to California. Marsh encouraged this, allowed new arrivals to stay on his ranch until they could get settled. Rancho Los Meganos became the terminus of the California Trail. Brentwood was named after Marsh's ancestral home, the town of Brentwood in the County of Essex, England. Brentwood's first post office was established in 1878; the city incorporated in 1948. Balfour, Guthrie & Co. a British investment company, purchased the John Marsh ranch in 1910. The company invested in other California agricultural properties as well. In 1910, it built the Brentwood Hotel at Oak Street and Brentwood Boulevard, across from the railroad station; this replaced an earlier hotel on the same site that had burned down in 1903. The hotel was razed in 1967, replaced by a service station; the Brentwood water tower symbolizes the city's transition from a rural farm community to a modern bedroom community.
This landmark on Walnut Boulevard, across the street from the Brentwood Park and Ride lot, is the tallest structure in the city. It now serves as a cell phone tower. City water is stored in large tanks atop hills outside the city; the city is bordered on three sides by the Contra Costa County Agricultural Core which consists of 11,000 acres of preserved and still productive farm land. During the 1990s, many types of retail stores were built along the Brentwood/Antioch border on Lone Tree Way, on both sides of SR 4 B, about 3.5 miles from downtown Brentwood. The Streets of Brentwood, an outdoor lifestyle retail center, opened in Brentwood in 2008; the city broke ground for a new civic center in November, 2009. The Mission-style architectural inspiration for City Hall, the main building, was the 1910 Brentwood Hotel; the $60 million project, completed in May 2012, includes the 58,000-square-foot City Hall and state-of-the-art City Council Chambers, a 32,000-square-foot community center, 280-space parking garage and redevelopment of the 1⁄2-acre City Park.
The community center includes arts and crafts rooms as well as studios for dance classes and community exercise programs. The center received a Leadership in Energy and Environmental Design silver certification for amenities such as green roofs, permeable paving and infiltration planters. City departments began moving into the new facility in October 2011, the former city hall was demolished during November 2011; as is common with many East Bay towns in Contra Costa County, Mount Diablo is seen from Brentwood. Brentwood is located on the alluvial plain of the Sacramento-San Joaquin Delta. In the picture shown at right, Brentwood lies the city of Antioch lies center left. North Peak appears in the foreground between the two cities and hides the city of Oakley; the East Bay Regional Park District is a special San Francisco Bay Area district operating in the East Bay counties of Alameda County and Contra Costa County. East Bay Regional Park District trails and parks are found in Brentwood. Brentwood has a total area of 14.81 sq mi, of which 14.79 sq mi is land and 0.02 sq mi or 0.13% is water.
The landscape on the west is marked by rolling hills, non-native
William Colbeck was a British seaman who distinguished himself on two Antarctic expeditions. William Colbeck was born on 8 August 1871, at Kingston-upon-Hull, Yorkshire, he was the fifth child in a family of ten born to Christopher Colbeck, a baker, his wife Martha. Educated at Hull Grammar School, Colbeck served a merchant navy apprenticeship on the Loch Torridon between 1886 and 1890 and completed a six-month course in navigation before going to sea, he earned his second mate's certificate in Calcutta in 1890, first mate's certificate in July 1892, master's in March 1894. He joined the firm of Tomas Wilson, Sons and Co, Ltd. of Hull and served on RMS Montebello as the second mate under Captain Pepper. He passed as extra master in November 1897, he was awarded a Royal Navy reserve commission in 1898. In that year he studied at Kew Observatory making a special feature of magnetism and it was in the capacity of Magnetic Observer that he was invited by the Norwegian Carsten Borchgrevink to join the Southern Cross Expedition to the Antarctic.
This would be the first expedition to overwinter on the Antarctic mainland. After returning to Britain in 1900, Colbeck was soon going southward again, this time in command of the relief ship Morning, sent to resupply Robert Falcon Scott's Discovery trapped in the ice at McMurdo Sound in the Antarctic, he was awarded the Royal Geographical Society's Back Award in 1901. On their way south the Morning celebrated Christmas Day 1902 by crossing the Antarctic Circle and discovering a uncharted island which they named Scott Island. Colbeck and three officers landed on the island where they had a drink; the adjacent cone-shaped islet Colbeck named Haggitt's Pillar, after his mother's maiden name. In January 1904, Colbeck returned with Morning, this time with firm instructions that unless Discovery could be speedily released from the ice, she was to be abandoned. In a race against time, with a fortunate shift in ice conditions, Discovery was freed and sailed safely home. Thereafter Colbeck made no further Antarctic ventures but resumed his job with the Wilson line in Hull.
In 1914 he went to work for the United Shipping Company of London becoming their Marine Superintendent. The family moved to south London, living at Catford. Captain Colbeck became a founder member of the Honourable Company of Master Mariners. In 1930 he was elected President of the Antarctic Club but died later that year of heart failure, after a bout of bronchitis, he is buried in Hither Green Cemetery. Colbeck married Edith Robinson and they had four sons. One of these, William Robinson Colbeck, joined the British Australia and New Zealand Antarctic expeditions of 1929–1931 as second officer and navigator in the old Discovery, he was responsible for much of the charting during the two voyages, the Colbeck Archipelago—off the Mawson Coast—is named after him. His work in the Antarctic was commemorated by the naming of Colbeck Bay at 71°38′S 170°5′E and Cape Colbeck on the King Edward VII peninsula, at 77°07′S 158°01′W. A plaque was placed on the site of his residence at 51 Inchmery Road, London SE6 in September 2016.
In the same year, a plaque was installed at Hull Paragon station, jointly commemorating Colbeck and Alfred Cheetham:'Two of many Hull seafarers on the ship Morning who participated in the Antarctic expeditions to relieve Captain Scott 1902-1904 and were welcomed by thousands at this station on their return'. William Colbeck’s second sledge flag as commanding officer of relief ship Morning has been lent to the National Maritime Museum by his family, it is the burgee of the Pirate Yacht Club, made of machine‑sewn wool bunting, printed with a skull and cross bones. The Pirate Yacht Club is no longer in existence having gone out of business before the First World War. Works by or about William Colbeck in libraries
Frederick Douglass is a public artwork in front of the Hornbake Library at the University of Maryland in College Park, Maryland. The statue memorializes African American abolitionist and labor leader, Frederick Douglass. Unveiled in 2015, the statue was designed by sculptor Andrew Edwards, inspired by artwork representing American president Barack Obama and Moses; the statue portrays Douglass in the middle of a speech, with one arm outstretched, a copy of his autobiography under the other arm. The square surrounding the statue features stone pavers and a vertical Corten steel wall with Douglass' words inscribed on them; the cast bronze statue was cast in Wales. It weighs nearly half a ton. Kenneth B. Morris, Jr. Douglass' great-great-great grandson, said that "I love that the statue shows him in his fiery abolitionist years."The statue was the result of years of efforts on the part of campus leaders to honor this important Marylander and to reaffirm commitment to social justice. University of Maryland professor of history Ira Berlin was part of a group of campus leaders who called themselves the North Stars, after the abolitionist newspaper Douglass edited.
According to Berlin, "The vision of myself and the North Stars was to have Frederick Douglass on campus to speak to the question of social justice." Efforts to raise the more than half a million dollars for the square and the statue began in 2011. The statue itself cost $200,000
William A. Barnhill was an American photographer best known for his work in the Appalachian Mountains of western North Carolina in the early 1900s, his love of hiking and photography took him to the mountains of western North Carolina between 1914 and 1917. The photographs he took during those trips have been featured in American Heritage and Life magazines, as well as in the collections of the Library of Congress, the New York Public Library, the Pack Memorial Public Library of Asheville, North Carolina, various college libraries. During World War I, as a Lieutenant in the US Army he commanded a photographic section in the 91st Aero Squadron; some of his photographs from the war were used in the New York Times during the war. He worked as a commercial photographer in Cleveland after the war. Library of Congress Barnhill photographs of pioneer life in western North Carolina, 1914-1917 New York Public Library - Romana Javitz Collection MFZ 93-6189. 1900s, in North Carolina, cityscapes of Cleveland and landscapes of a covered bridge near Mechanicsville, Ohio, ca.
1930s, landscapes of the Delaware & Raritan Canal in Pennsylvania, ca. 1910. Asheville--the mountains, the people: an historical photographic collection / edited by Edward Epstein, John Toms, Peter Vari of the Asheville-Buncombe Library System. Featuring photograph by William A. Barnhill and others Life Magazine Oct 16, 1970 A two-page spread of Barnhill's photograph of an Appalachian family carding and weaving wool American Heritage February 1969 Richard M. Ketchum, "Appalachia 1914," American Heritage 20: 26-41, 85. Search Pack Memorial Library Collection for Images by Barnhill Photos by William A. Barnhill Byways of Cleveland, a collection of 61 photographs by Barnhill available on the Cleveland Public Library Digital Gallery
Gorgi Popstefanov is a Macedonian road racing cyclist. He is the 2016 Macedonian Men's Elite Road Race Champion. Gorgi represented Macedonia twice at the UCI World Championships, including Ponferrada 2014 and Richmond 2015. Gorgi immigrated with his family from SR Macedonia to the United States at the age of 2 and has since split much of his time between the two countries, he grew up in Garfield, New Jersey, graduated from Seton Hall Preparatory School in West Orange, New Jersey in 2005 and received a B. A. in International Affairs from George Washington University's Elliott School of International Affairs in 2009, where he was a member of the varsity crew team. As of May 2013 he completed a J. D. in International Law at Seton Hall University School of Law. 2010 1st National Road Race Championships 2016 1st National Road Race Championships 2018 3rd National Time Trial Championships
Polyketide synthases are a family of multi-domain enzymes or enzyme complexes that produce polyketides, a large class of secondary metabolites, in bacteria, plants, a few animal lineages. The biosyntheses of polyketides share striking similarities with fatty acid biosynthesis; the PKS genes for a certain polyketide are organized in one operon or in gene clusters. PKSs can be classified into three groups with the following subdivisions: Type I polyketide synthases are large modular proteins. Iterative Type I PKSs reuse domains in a cyclic fashion. NR-PKSs — non-reducing PKSs, the products of which are true polyketides PR-PKSs — reducing PKSs FR-PKSs — reducing PKSs, the products of which are fatty acid derivatives Modular Type I PKSs contain a sequence of separate modules and do not repeat domains. Type II polyketide synthases are aggregates of monofunctional proteins. Type III polyketide synthases do not use ACP domains; each type I polyketide-synthase module consists of several domains with defined functions, separated by short spacer regions.
The order of modules and domains of a complete polyketide-synthase is as follows: Starting or loading module: AT-ACP- Elongation or extending modules: -KS-AT--ACP- Termination or releasing domain: -TEDomains: AT: Acyltransferase ACP: Acyl carrier protein with an SH group on the cofactor, a serine-attached 4'-phosphopantetheine KS: Keto-synthase with an SH group on a cysteine side-chain KR: Ketoreductase DH: Dehydratase ER: Enoylreductase MT: Methyltransferase O- or C- SH: PLP-dependent cysteine lyase TE: ThioesteraseThe polyketide chain and the starter groups are bound with their carboxy functional group to the SH groups of the ACP and the KS domain through a thioester linkage: R-COH + HS-protein <=> R-CS-protein + H2O. The ACP carrier domains are similar to the PCP carrier domains of nonribosomal peptide synthetases, some proteins combine both types of modules; the growing chain is handed over from one thiol group to the next by trans-acylations and is released at the end by hydrolysis or by cyclization.
Starting stage: The starter group acetyl-CoA or its analogues, is loaded onto the ACP domain of the starter module catalyzed by the starter module's AT domain. Elongation stages: The polyketide chain is handed over from the ACP domain of the previous module to the KS domain of the current module, catalyzed by the KS domain; the elongation group malonyl-CoA or methylmalonyl-CoA, is loaded onto the current ACP domain catalyzed by the current AT domain. The ACP-bound elongation group reacts in a Claisen condensation with the KS-bound polyketide chain under CO2 evolution, leaving a free KS domain and an ACP-bound elongated polyketide chain; the reaction takes place at the KSn-bound end of the chain, so that the chain moves out one position and the elongation group becomes the new bound group. Optionally, the fragment of the polyketide chain can be altered stepwise by additional domains; the KR domain reduces the β-keto group to a β-hydroxy group, the DH domain splits off H2O, resulting in the α-β-unsaturated alkene, the ER domain reduces the α-β-double-bond to a single-bond.
It is important to note that these modification domains affect the previous addition to the chain, not the component recruited to the ACP domain of the module containing the modification domain. This cycle is repeated for each elongation module. Termination stage: The TE domain hydrolyzes the completed polyketide chain from the ACP-domain of the previous module. Polyketide synthases are an important source of occurring small molecules used for chemotherapy. For example, many of the used antibiotics, such as tetracycline and macrolides, are produced by polyketide synthases. Other industrially important polyketides are sirolimus, erythromycin and epothilone B. Only about 1% of all known molecules are natural products, yet it has been recognized that two thirds of all drugs in use are at least in part derived from a natural source; this bias is explained with the argument that natural products have co-evolved in the environment for long time periods and have therefore been pre-selected for active structures.
Polyketide synthase products include lipids with antibiotic, antifungal and predator-defense properties. Methods for the detection of novel polyketide synthase pathways in the environment have therefore been developed. Molecular evidence supports the notion that many novel polyketides remain to be discovered from bacterial sources. Doxorubicin Polyketide+synthases at the US National Library of Medicine Medical Subject Headings