"Brian & Stewie" is the 17th episode of the eighth season of the American animated television series Family Guy. It originally aired on Fox in the United States on May 2, 2010. The episode features Brian and Stewie after they are accidentally trapped inside a bank vault over a weekend. The two try to kill each other, and are ultimately forced to reveal their true feelings about each other, and eventually go on to question each other's existence and purpose in life. Brian and Stewie become even closer to each other as time goes on, and climactically help each other survive being trapped inside the vault. The bottle episode breaks from the show's usual set-up, and is the only episode of the series not to feature any music or use any cutaway gags with Brian and Stewie being the only two characters featured in the entire episode. In repeats of the episode there is no main title sequence, nor is any music played over the end credits.

The American adult animated sitcom Family Guy has been the target of numerous taste and indecency complaints. The show is known to include offensive jokes including racial humor and violent, gory, and disturbing images.