Brices Cross Roads National Battlefield Site memorializes the Battle of Brice's Cross Roads, in which a U.S. Army force was defeated by a smaller Confederate force commanded by Major-General Nathan Bedford Forrest on June 10, 1864, but nonetheless secured Union supply lines between Nashville and Chattanooga, Tennessee.

The Battle of Brice's Cross Roads, also known as the Battle of Tishomingo Creek or the Battle of Guntown, was fought on Friday, June 10, 1864, near Baldwyn, Mississippi, then part of the Confederate States of America. A Federal expedition from Memphis, Tennessee, of 4,800 infantry and 3,300 cavalry, under the command of Brigadier-General Samuel D. Sturgis, was defeated by a Confederate force of 3,500 cavalry under the command of Major-General Nathan B. Forrest. The battle was a victory for the Confederates. Forrest inflicted heavy casualties on the Federal force and captured more than 1,600 prisoners of war, 18 artillery pieces, and wagons loaded with supplies. Once Sturgis reached Memphis, he asked to be relieved of his command.