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British Independent Film Awards

The British Independent Film Awards is an organisation that celebrates and promotes British independent cinema and filmmaking talent in United Kingdom. Nominations for the annual awards ceremony are announced in early November, with the ceremony itself taking place in early December. Since 2015, BIFA has hosted UK-wide talent development and film screening programmes with the support of Creative Skillset and the British Film Institute; the British Independent Film Awards were created in 1998 by Elliot Grove and Suzanne Ballantyne of the Raindance Film Festival, with the aim of celebrating merit and achievement in independently funded British filmmaking, honouring new talent and promoting British films and filmmaking to a wider public audience. BIFA founding members include Phillip Alberstat, Chris Auty, André Burgess, Sally Caplan, Pippa Cross, Christopher Fowler, Lora Fox Gamble, Steven Gaydos, Norma Heyman, Emma E. Hickox, Fred Hogge, Robert Jones, Steve Kenis, Alberto Lopez, Ollie Madden, Hamish McAlpine, Neil McCartney, Saul Metzstein, Martin Myers, Sarah Radclyffe, Tracey Scoffield, Mark Shivas, Jim Wilson, Michiyo Yoshizaki.

The first BIFA ceremony took place on 29 October 1998. Winners included Shane Meadows and Ray Winstone; the Special Jury Prize was awarded to Nik Powell, the Best British Independent Film award went to My Name is Joe. The BIFA ceremony takes place in early December every year and is one of the first dates in the annual awards season. Most of the awards categories are for British independent feature films only, though there are awards for Best International Independent Film and Best British Short Film. There are several honorary awards, such as the Special Jury Prize, the Richard Harris Award and the Variety Award. Awarded since 2013, the trophy has been a sculpture by Fredrikson Stallard for Swarovksi. BIFA has 16 competitive award categories and three honorary ones: Best British Independent Film Best Director Best Screenplay Best Actor Best Actress Best Supporting Actor Best Supporting Actress Outstanding Achievement in Craft The Douglas Hickox Award Best Debut Screenwriter Breakthrough Producer Most Promising Newcomer The Discovery Award Best Documentary Best British Short Film Best International Independent Film The Richard Harris Award The Variety Award The Special Jury Prize BIFA entries close in late August / early September.

Main categories: Films must be over 70 minutes in length. Films must have had a public screening to a paying audience, either on general release in the UK or at a British film festival or at one of BIFA's recognised international festivals. Must be produced or majority co-produced by a British production company, or be in receipt of at least 51% of its budget from British source and have sufficient British creative elements. Where there is a major studio funding a film, the total budget must not exceed $20 million. Best International Independent Film: Films must have had a theatrical release in the UK within BIFA's eligibility dates for the given year, or have won an award at one of BIFA's recognised international film festivals. BIFA has a large pool of voters that consists of past BIFA winners and nominees, top British film industry professionals and experienced filmmakers from all areas of production. Although the pool is continually growing, fewer than 200 voters vote for the nominations in any one year.

All entered films must be seen by a minimum number of voters and discussed at a voter meeting before being marked as having been given fair consideration. Once all entered films have been given fair consideration, votes are cast in two rounds: once to reduce all entries to long lists of around 15 films in each category, again to reduce the long lists to the 5 final nominees. In calculating the results, BIFA takes into account the number of voters who have seen each film as well as how many voted for it; the winners in most categories are decided by independent juries, newly–appointed each year. Juries meet to discuss all nominations before voting confidentially for the winner. Exceptions include the honorary awards and the award for Best British Independent Film, the winner of, decided by a confidential vote amongst all BIFA voters. Since 2015, BIFA has hosted UK–wide talent development and film screening programmes with the support of Creative Skillset and the BFI. Running from September 2015 to June 2016, BIFA Insider gave UK–based university and film school students the chance to watch award-winning British films for free online and participate in live-streamed Q&As with top craftspeople who worked on those films.

Sessions included The Lobster with production designer Jaqueline Abrahams, The Selfish Giant with casting director Amy Hubbard and Frank with composer Stephen Rennicks. BIFA Presents is an ongoing project wherein BIFA supports the theatrical distribution of award-nominated and -winning films with special preview and event screenings. In February 2017, BIFA Presents hosted exclusive previews of the Oscar-winning Moonlight in conjunction with Everyman Cinemas. BIFA Independents is a series of regular screenings of films featuring BIFA-winning and nominated talent. Supported by the BFI, Odeon Cinemas, Vue Cinemas and Everyman Cinemas, the screenings take place in 20 UK locations and aim to increase the number of people who watch British independent films at the cinema; the first BIFA Independents screening was in December 2016, featuring Andrea Arnold's Best British Independent Film-winning American Honey. BIFA Patrons include: Official website IMDb page

FPG IleRS zinc finger

The FPG IleRS zinc finger domain represents a zinc finger domain found at the C-terminal in both DNA glycosylase/AP lyase enzymes and in isoleucyl tRNA synthetase. In these two types of enzymes, the C-terminal domain forms a zinc finger. DNA glycosylase/AP lyase enzymes are involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; these enzymes have both DNA glycosylase activity and AP lyase activity. Examples include formamidopyrimidine-DNA glycosylases and endonuclease VIII. Formamidopyrimidine-DNA glycosylases is a trifunctional DNA base excision repair enzyme that removes a wide range of oxidation-damaged bases and cleaves both the 3'- and 5'-phosphodiester bonds of the resulting apurinic/apyrimidinic site. Fpg has a preference for oxidised purines, excising oxidized purine bases such as 7,8-dihydro-8-oxoguanine. ITs AP lyase activity introduces nicks in the DNA strand, cleaving the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.

Fpg is a monomer composed of 2 domains connected by a flexible hinge. The two DNA-binding motifs suggest that the oxidized base is flipped out from double-stranded DNA in the binding mode and excised by a catalytic mechanism similar to that of bifunctional base excision repair enzymes. Fpg binds one ion of zinc at the C terminus, which contains four essential cysteines. Endonuclease VIII has the same enzyme activities as Fpg above, but with a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. An Fpg-type zinc finger is found at the C terminus of isoleucyl tRNA synthetase; this enzyme catalyses the attachment of isoleucine to tRNA. As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA-dependent editing activities. One activity is designated as'pre-transfer' editing and involves the hydrolysis of activated Val-AMP; the other activity is designated'post-transfer' editing and involves deacylation of mischarged Val-tRNA

Fatehabad Chandrawatiganj Junction railway station

Fatehabad Chandrawatiganj Junction is a railway station in Ujjain. The station was used as a meter gauge station on Ratlam–Indore line. Fatehabad has a connecting route to Ujjain Junction on meter gauge line. In 2015, Ratlam-Indore was converted into broad gauge line, directly connecting Ratlam. Fatehabad and Chandrawati Ganj are two villages on the Indore Ujjain district border. Fatehabad village is under Ujjain district and Chandrawati Ganj is under Indore district. Four trains stop at Fatehabad Chandrawatiganj junction: 79312/79311 Laxmibai Nagar - Ratlam DEMU 79305/79306 Ratlam - Indore DMU 14801/14802 Jodhpur - Indore Express Indore Junction Ujjain Junction