Brooke County is a county in the Northern Panhandle of the U.S. state of West Virginia. As of the 2020 census, the population was 22,559. Its county seat is Wellsburg. The county was created in 1797 from part of Ohio County and named in honor of Robert Brooke, Governor of Virginia from 1794 to 1796. Brooke County is part of the Weirton-Steubenville, WV-OH Metropolitan Statistical Area, which is also included in the Pittsburgh-New Castle-Weirton, PA-WV-OH Combined Statistical Area.

Wellsburg is a city in and the county seat of Brooke County, West Virginia, United States. The 2020 census recorded a population of 2,455. It is a part of the Weirton–Steubenville metropolitan area. The city's economy includes several telemarketing facilities, and a factory that does metal fabrication and plastics molding.