The Bucaramanga-Santa Marta Fault or Bucaramanga-Santa Marta Fault System is a major oblique transpressional sinistral strike-slip fault in the departments of Magdalena, Cesar, Norte de Santander and Santander in northern Colombia. The fault system is composed of two main outcropping segments, named Santa Marta and Bucaramanga Faults, and an intermediate Algarrobo Fault segment in the subsurface. The system has a total length of 674 kilometres (419 mi) and runs along an average north-northwest to south-southeast strike of 341 ± 23 from the Caribbean coast west of Santa Marta to the northern area of the Eastern Ranges of the Colombian Andes.

The Middle Magdalena Valley, Middle Magdalena Basin or Middle Magdalena Valley Basin is an intermontane basin, located in north-central Colombia between the Central and Eastern Ranges of the Andes. The basin, covering an area of 34,000 square kilometres (13,000 sq mi), is situated in the departments of Santander, Boyacá, Cundinamarca and Tolima.