Jame Gumb is a fictional character and the main antagonist of Thomas Harris's 1988 novel The Silence of the Lambs and its 1991 film adaptation, in which he is played by Ted Levine. In the film and the novel, he is a serial killer who murders overweight women and skins them so he can make a "woman suit" for himself. In the television series Clarice, he is portrayed by Simon Northwood.

The Silence of the Lambs is a 1991 American psychological horror thriller film directed by Jonathan Demme and written by Ted Tally, adapted from Thomas Harris's 1988 novel of the same name. It stars Jodie Foster as Clarice Starling, a young FBI trainee who is hunting a serial killer named "Buffalo Bill", who skins his female victims. To catch him, she seeks the advice of the imprisoned Dr. Hannibal Lecter, a brilliant psychiatrist and cannibalistic serial killer. The film also features performances from Scott Glenn, Anthony Heald, and Kasi Lemmons.