The Buick LaCrosse is a four-door, front-wheel-drive sedan manufactured by Buick since model year 2005, and marketed variously across four generations for the North American and Chinese markets.

Buick is a division of the American automobile manufacturer General Motors (GM). Started by automotive pioneer David Dunbar Buick in 1899, it was among the first American automobile brands and was the company that established General Motors in 1908. Before the establishment of General Motors, GM founder William C. Durant had served as Buick's general manager and major investor. With the demise of Oldsmobile in 2004, Buick became the oldest surviving American carmaker.