The Burin Peninsula is a peninsula located on the south coast of the island of Newfoundland in the province of Newfoundland and Labrador. Marystown is the largest population centre on the peninsula.

Route 220 is the southern portion of the Heritage Run in the Canadian province of Newfoundland and Labrador, running along the southern and western coastlines of the Burin Peninsula of Newfoundland. It is a loop road, running due south from the town of Marystown and continues until the town of Grand Bank where it transitions into Route 210 - and vice versa. The speed limit along much of Route 220 is 80 km/h, except in communities where the speed limit is reduced to 50 km/h.