Busch Memorial Stadium was a multi-purpose sports facility in St. Louis, Missouri, that operated for 40 years, from 1966 through 2005. Built as Civic Center Busch Memorial Stadium, its official name was shortened to Busch Stadium in January 1982.

The 2005 National League Championship Series (NLCS), the second round of the 2005 National League playoffs, matched the Central Division champion and defending league champion St. Louis Cardinals against the wild card qualifier Houston Astros, a rematch of the 2004 NLCS. The Cardinals, by virtue of having the best record in the NL during the 2005 season, had the home-field advantage. The Astros won the series four games to two, and became the National League champions; they faced the American League champion Chicago White Sox in the 2005 World Series, where the Astros lost to the White Sox in a sweep in four games.