Cölbe station is a junction station on the Main-Weser Railway in the town of Cölbe in the German state of Hesse. Here the Upper Lahn Valley Railway to Erndtebrück via Biedenkopf and Bad Laasphe and the Burgwald Railway to Frankenberg (Eder) via Wetter and Münchhausen branch off the main line. It has four platform tracks and a passing loop. The station is classified by Deutsche Bahn (DB) as a category 5 station. The Baroque Revival station is heritage-listed under the Hessian Heritage Act.

The Main–Weser Railway is a railway line in central Germany that runs from Frankfurt am Main via Gießen to Kassel. it is named after the railway company that built the line and also operated it until 1880. It was opened between 1849 and 1852 and was one of the first railways in Germany.