The first case relating to the COVID-19 pandemic in London, England, was confirmed on 12 February 2020 in a woman who had recently arrived from China. By March 2020, there had been almost 500 confirmed cases in the city, and 23 deaths; a month later, the number of deaths had topped 4,000.

The COVID-19 pandemic was first confirmed to have spread to England with two cases among Chinese nationals staying in a hotel in York on 31 January 2020. The two main public bodies responsible for health in England were NHS England and Public Health England (PHE). NHS England oversees the budget, planning, delivery and day-to-day operation of the commissioning side of the NHS in England, while PHE's mission is "to protect and improve the nation's health and to address inequalities". As of 14 September 2021, there have been 6,237,505 total cases and 117,955 deaths in England. In January 2021, it was estimated around 22% of people in England have had COVID-19.