The COVID-19 pandemic in Vatican City was a part of the worldwide pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2. The Holy See reported the first case of infection in Vatican City on 7 March 2020. Unlike other jurisdictions that report cases within a given territory or cases of residents or citizens of a territory, the Holy See reports on cases "in Vatican City State and among the employees of the Holy See" regardless of location of testing, treatment, or residence. There were 29 confirmed cases of COVID-19 among the Vatican's residents and employees; there were no associated deaths. The 29 cases included 10 employees, 1 new hire, and 1 resident of Vatican City. All those infected tested negative by 6 June 2020. An outbreak among members of the Holy See's Swiss Guard was reported in mid-October, totaling 11 as of October 15.

This is a general overview and status of places affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus which causes coronavirus disease 2019 (COVID-19) and is responsible for the COVID-19 pandemic. The first human cases of COVID-19 were identified in Wuhan, the capital of the province of Hubei in China in December 2019.