Beginning in early April 2020, there were protests in several U.S. states against government-imposed lockdowns in response to the COVID-19 pandemic in the United States. The protests, mostly organized by conservative groups and individuals, decried the economic and social impact of stay-at-home orders, business closures, and restricted personal movement and association, and demanded that their respective states be "re-opened" for normal business and personal activity.

During the early stages of the COVID-19 pandemic, a number of non-pharmaceutical interventions, particularly lockdowns, were implemented in numerous countries and territories around the world. These restrictions were established with the intention to reduce the spread of SARS-CoV-2, the virus that causes COVID-19. By April 2020, about half of the world's population was under some form of lockdown, with more than 3.9 billion people in more than 90 countries or territories having been asked or ordered to stay at home by their governments. Although similar disease control measures have been used for hundreds of years, the scale of those implemented in the 2020s is thought to be unprecedented.