Cable & Deadpool was a comic book series published by Marvel Comics beginning in 2004. The title characters, Cable and Deadpool, shared the focus of the book. The series was launched following the cancellation of the characters' previous ongoing solo series. The book's mix of humor, action, and intricate plotting have won it a devoted fanbase. Marvel Comics canceled the series with issue #50 to make way for a new Deadpool ongoing series that began on September 10, 2008, and a new Cable ongoing series that was launched in March 2008. Cable & Deadpool were ranked #7 on Marvel.com's list of "The 10 Greatest Buddy Teams" of all time.

Cable is a character appearing in American comic books published by Marvel Comics, commonly in association with X-Force and the X-Men. Nathan first appeared as the newborn infant in The Uncanny X-Men #201 created by writer Chris Claremont and penciler Rick Leonardi, while Cable first appeared in The New Mutants #87 created by writer Louise Simonson and artist/co-writer Rob Liefeld; Cable's origin initially was undecided and he was assumed to be a separate character, but it was later decided that he was actually an older version of Nathan due to being a time traveler.