The Cache River National Wildlife Refuge is a 68,993 acre (223 km2) (2014) wildlife refuge in the state of Arkansas managed by the United States Fish and Wildlife Service (FWS). The refuge is one of the Ramsar wetlands of international importance under the Ramsar Convention signed in 1971. It is one of the most important wintering area for ducks and the largest remaining tract of contiguous bottomland hardwood forest on the North American continent. In 2005, a possible sighting of the ivory-billed woodpecker, thought to be extinct, brought attention to the refuge.

The ivory-billed woodpecker is a woodpecker that is native to the bottomland hardwood forests and temperate coniferous forests of the Southern United States and Cuba. Habitat destruction and hunting have reduced populations so thoroughly that the species is listed by the International Union for Conservation of Nature (IUCN) on its Red List as critically endangered, and by the American Birding Association as "definitely or probably extinct". The last universally accepted sighting of an American ivory-billed woodpecker occurred in Louisiana in 1944, and the last universally accepted sighting of a Cuban ivory-billed woodpecker occurred in 1987, after the bird's rediscovery there the prior year. Sporadic reports of sightings and other evidence of the persistence of the species have continued since then.