Caddo is a town in Bryan County, Oklahoma, United States. The population was 997 at the 2010 census, a 5.6 percent gain over the figure of 944 recorded in 2000. The name is derived from a Caddo word, ka do hada’ cho, meaning "real chief" in English. According to Encyclopedia of Oklahoma History and Culture, the town was named for the nearby Caddo Hills.

Bryan County is a county in the U.S. state of Oklahoma. As of the 2020 census, the population was 46,067. Its county seat is Durant. It is the only county in the United States named for Democratic politician William Jennings Bryan.