Cairo is a village in Hall County, Nebraska, United States. The population was 785 at the 2010 census. It is part of the Grand Island, Nebraska Micropolitan Statistical Area.

Hall County is a county in the U.S. state of Nebraska. As of the 2020 United States Census, the population was 62,895, making it Nebraska's fourth-most populous county. Its county seat is Grand Island. The county was formed in 1858; it was named for Augustus Hall, an early judge of this territory.