Calhoun City is a town in Calhoun County, Mississippi, United States. The population was 1,774 at the 2010 census.

Calhoun County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 13,266. Its county seat is Pittsboro. The county is named after John C. Calhoun, the U.S. Vice President and U.S. Senator from South Carolina.