Calhoun County is a county located in the south central part of the U.S. state of Arkansas. As of the 2020 census, the population was 4,739, making it the least populous county in Arkansas. The county seat is Hampton. Calhoun County is Arkansas's 55th county, formed on December 6, 1850, and named for John C. Calhoun, a Vice President of the United States.

Hampton is a town in Calhoun County, Arkansas, United States. The population was 1,181 according to the 2020 United States Census. The town is the county seat of Calhoun County.