Calhoun County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 13,266. Its county seat is Pittsboro. The county is named after John C. Calhoun, the U.S. Vice President and U.S. Senator from South Carolina.

Pittsboro is a village in Calhoun County, Mississippi, United States. The population was 202 at the 2010 census. It is the county seat of Calhoun County.