Calhoun County is a county in the U.S. state of South Carolina. As of the 2020 census, its population was 14,119, making it the third-least populous county in the state. Its county seat is St. Matthews. In terms of land area, it is also the smallest county in the state.

The 2022 South Carolina gubernatorial election took place on November 8, 2022, to elect the governor of South Carolina. Incumbent Republican Governor Henry McMaster ran for re-election for a second full term in office and secured the Republican nomination in the June 14 primary. Joe Cunningham, former United States Representative from South Carolina's 1st congressional district, was the Democratic nominee. McMaster won the general election with 58% of the vote — a larger margin than in 2018.