Calibre 50 is a regional Mexican band. Formed in Mazatlán, Sinaloa, in 2010 by Edén Muñoz, the band has had several lineup changes, with the current roster consisting of lead vocalist Beto Gastélum, lead vocalist & twelve-string guitarist Tony Elizondo, diatonic accordionist Martín "Trompudo" López, sousaphonist Alejandro Gaxiola, and drummer Erick García.

Regional Mexican music refers collectively to the regional subgenres of the country music of Mexico and its derivatives from the Southwestern United States. Each subgenre is representative of a certain region and its popularity also varies by regions. Subgenres include banda, duranguense, grupero, mariachi, New Mexico music, Norteño, Sierreño, Tejano, and Tierra Caliente. It is among the most popular radio formats targeting Mexican Americans in the United States.