California Polytechnic State University, San Luis Obispo is a public university in San Luis Obispo County, adjacent to the city of San Luis Obispo. It is the oldest of three polytechnics in the California State University system.

Jamba Juice, doing business as Jamba, is an American quick-service restaurant and juice bar chain that sells blended fruit and vegetable juices, smoothies and other food products. The first Jamba Juice location, originally named Juice Club, opened in 1990 in San Luis Obispo, California. Jamba is owned by Focus Brands, an affiliate of private equity firm Roark Capital Group, which completed its acquisition in 2019. The company has more than 850 locations operating in 36 states in the United States, and also has locations in Australia, Japan, the Philippines, Taiwan, South Korea, Thailand, and Indonesia.