The California Science Center is a state agency and museum located in Exposition Park, Los Angeles, next to the Natural History Museum of Los Angeles County and the University of Southern California. Billed as the West Coast's largest hands-on science center, the California Science Center is a public-private partnership between the State of California and the California Science Center Foundation. The California Natural Resources Agency oversees the California Science Center and the California African American Museum. Founded in 1951 as the "California Museum of Science and Industry", the Museum was remodeled and renamed in 1998 as the "California Science Center". The California Science Center hosts the California State Science Fair annually.

Exposition Park is a 160-acre urban park (65 ha) in the south region of Los Angeles, California, in the Exposition Park neighborhood. Established in 1872 as an agricultural fairground, the park includes the Los Angeles Memorial Coliseum, BMO Stadium, the California Science Center, the Natural History Museum of Los Angeles County, and the California African American Museum. The Lucas Museum of Narrative Art is under construction. Bounded by Exposition Boulevard to the north, South Figueroa Street to the east, Martin Luther King Jr. Boulevard to the south and Vermont Avenue to the west, it is directly south of the main campus of the University of Southern California.