State Route 115 is a state highway in the U.S. state of California. It runs in Imperial County from Interstate 8 (I-8) southeast of Holtville to SR 111 in Calipatria. The routing was added to the state highway system in 1933, and was constructed by 1934; SR 115 was officially designated in the 1964 state highway renumbering.

Holtville is a city in Imperial County, California. Holtville is located 10.5 miles (17 km) east of El Centro. The population was 5,939 at the 2010 census, up from 5,612 in 2000.