State Route 163 (SR 163), or the Cabrillo Freeway, is a state highway in San Diego, California. The 11.088-mile (17.844 km) stretch of the former US 395 freeway runs from Downtown San Diego just south of an interchange with Interstate 5 (I-5), extending north through historic Balboa Park and various neighborhoods of San Diego to an interchange with I-15 in the neighborhood of Miramar. The freeway is named after Juan Rodríguez Cabrillo, the first European to navigate the coast of present-day California.

U.S. Route 395 (US 395) is a United States Numbered Highway, stretching from Hesperia, California to the Canadian border in Laurier, Washington. The California portion of US 395 is a 557-mile (896 km) route which traverses from Interstate 15 (I-15) in Hesperia, north to the Oregon state line in Modoc County near Goose Lake. The route clips into Nevada, serving the cities Carson City and Reno, before returning to California.