State Route 2 (SR 2) is a state highway in the U.S. state of California. It connects the Los Angeles Basin with the San Gabriel Mountains and the Victor Valley in the Mojave Desert. The highway's southwestern end is at the intersection of Centinela Avenue at the Santa Monica-Los Angeles border and its northeastern end is at SR 138 east of Wrightwood. The SR 2 is divided into four segments, and it briefly runs concurrently with U.S. Route 101 (US 101) and Interstate 210 (I-210). The southwestern section of SR 2 runs along a segment of the east–west Santa Monica Boulevard, an old routing of US 66, to US 101 in East Hollywood; the second section runs along segments of both the north–south Alvarado Street and Glendale Boulevard in Echo Park; the third section to I-210 in Glendale is known as the north–south Glendale Freeway; and the northeastern portion from I-210 in La Cañada Flintridge to SR 138 is designated as the Angeles Crest Highway.

The San Gabriel Mountains comprise a mountain range located in northern Los Angeles County and western San Bernardino County, California, United States. The mountain range is part of the Transverse Ranges and lies between the Los Angeles Basin and the Mojave Desert, with Interstate 5 to the west and Interstate 15 to the east. The range lies in, and is surrounded by, the Angeles and San Bernardino National Forests, with the San Andreas Fault as its northern border.