State Route 52 (SR 52) is a state highway in San Diego County, California, that extends from La Jolla Parkway at Interstate 5 (I-5) in La Jolla, San Diego, to SR 67 in Santee. It is a freeway for its entire length and serves as a major east–west route through the northern part of the city of San Diego. The road connects the major north–south freeways of the county, including I-5, I-805, SR 163, I-15, SR 125, and SR 67. SR 52 passes north of the Rose Canyon Fault before traversing Marine Corps Air Station Miramar. East of Santo Road and west of SR 125, the highway goes through Mission Trails Regional Park, a large open preserve. SR 52 is also known as the Soledad Freeway and the San Clemente Canyon Freeway.

Interstate 5 (I-5) is a major north–south route of the Interstate Highway System in the United States, stretching from the Mexican border at the San Ysidro crossing to the Canadian border near Blaine, Washington. The segment of I-5 in California runs 796.77 miles (1,282.28 km) across the length of the state from San Ysidro to the Oregon state line south of the Medford-Ashland metropolitan area. It is the longest interstate in California, and accounts for more than half of I-5's total length.