State Route 72 is a state highway in the U.S. state of California. The route runs along Whittier Boulevard in the Los Angeles area from SR 39 in La Habra to Interstate 605 in Whittier. SR 72 forms part of El Camino Real.

Whittier Boulevard is an arterial street that runs from the Los Angeles River to Brea, California. The street is one of the main thoroughfares in both Whittier and East Los Angeles. At various times, portions of Whittier Boulevard carried the designation of U.S. Route 101. Whittier Boulevard also carries a portion of El Camino Real. Its west section leading from the Sixth Street Viaduct was demolished in 2016; the replacement was officially opened in 2022.. Currently, Whittier Boulevard carries two Caltrans controlled highways. The portion between Rosemead Boulevard and Beach Boulevard carries State Route 72 and the portion between Beach and Harbor Boulevards carries California State Route 39. The portion of State Route 72 up to State Route 19 was relinquished back to Pico Rivera in the early 2000s and the portion of State Route 72 between State Route 19 and Downey Road was deleted from SR 72 in 1992.