Calmodulin
Videos
Calmodulin is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the binding of Ca2+
The helix–loop–helix structure of the calcium-binding EF hand motif
Solution structure of Ca2+-calmodulin C-terminal domain
Solution structure of Ca2+-calmodulin N-terminal domain
Calmodulin bound to a peptide from MLC kinase (PDB: 2LV6)
Ca2+/calmodulin-dependent protein kinase II is a serine/threonine-specific protein kinase that is regulated by the Ca2+/calmodulin complex. CaMKII is involved in many signaling cascades and is thought
Calmodulin
…to wrap around its target, although alternate modes of binding are known. "Canonical" targets of calmodulin, such as myosin light-chain kinases and CaMKII, bind only to the Ca2+-bound protein, whereas some proteins, such as NaV channels and IQ-motif proteins, also bind to calmodulin in the absence of Ca2…
Crystal structure of calcium/calmodulin-dependent protein kinase
CaMKII gamma holoenzyme in its (A) closed and the (B) open conformations
The structure of the association domain of CaMKII gamma rendered by pymol from PDB 2ux0 (left) space fill holoenzyme (center) cartoon holoemzyme (right) cartoon monome
The structure of the kinase domain of CaMKII (gamma) rendered by pymol from PDB 2v7O, green sticks = nucleotide