"Can't Leave 'em Alone" is a R&B song recorded by American singer Ciara featuring rapper 50 Cent for Ciara's second album, Ciara: The Evolution (2006). Written by Ciara, LaShawn Daniels, Rodney Jerkins, and 50 Cent, it is the fourth release and official third single from the album. It was solicited to Mainstream Urban radio stations on June 12, 2007 and Rhythmic stations on July 10, 2007.

Ciara: The Evolution is the second studio album by American singer Ciara, released on December 5, 2006, by LaFace Records. The album is separated into five sections, with each showcasing a different side of Ciara's artistry. The first features crunk&B and uptempo records, which mainly deal with feminine independence, while its successor, entitled The Evolution of Music features ballads dealing with the positives and struggles of love. The Evolution of Dance features dance tracks, The Evolution of Fashion deals with self-expression, while the last, entitled The Evolution of C, features tracks that discuss how Ciara has evolved as a person since the start of her career.