The Canton–Massillon Metropolitan Statistical Area, as defined by the United States Census Bureau, is an area consisting of two counties in Northeast Ohio, anchored by the cities of Canton and Massillon. As of the 2020 census, the MSA had a population of 401,574. The MSA is also part of the Cleveland–Akron–Canton, OH Combined Statistical Area, which had a population of 3,633,962 in 2020, making it the largest CSA in Ohio.

The region Northeast Ohio, in the US state of Ohio, in its most expansive usage contains six metropolitan statistical areas: Cleveland–Elyria, Akron, Canton–Massillon, Youngstown–Warren, Mansfield, and Weirton–Steubenville along with eight micropolitan statistical areas. Most of the region is considered either part of the Cleveland–Akron–Canton, OH Combined Statistical Area and media market or the Youngstown–Warren, OH–PA Combined Statistical Area and media market. In all, the region is home to: 4,502,460 residents. It is also a part of the Great Lakes megalopolis, containing over 54 million people. Northeast Ohio also includes most of the area known historically as the Connecticut Western Reserve.