Cape Hatteras National Seashore is a United States national seashore which preserves the portion of the Outer Banks of North Carolina from Bodie Island to Ocracoke Island, stretching over 70 miles (110 km), and is managed by the National Park Service. Included within this section of barrier islands along N.C. 12, but outside the national seashore boundaries, are Pea Island National Wildlife Refuge and several communities, such as Rodanthe, Buxton, and Ocracoke. Cape Hatteras is a combination of natural and cultural resources, and provides a wide variety of recreational opportunities.

Fort Raleigh National Historic Site preserves the location of Roanoke Colony, the first English settlement in the present-day United States. The site was preserved for its national significance in relation to the founding of the first English settlement in North America in 1587. The colony, which was promoted and backed by entrepreneurs led by Englishman Sir Walter Raleigh, failed sometime between 1587 and 1590 when supply ships failed to arrive on time. When next visited, the settlement was abandoned with no survivors found. The fate of the "Lost Colony" was a celebrated mystery, although most modern academic sources agree that the settlers likely assimilated into local indigenous tribes.