The Cape Henlopen Region, or the Cape Region, is a region in Sussex County, in southern Delaware, on the Delmarva Peninsula. The region is part of the Salisbury, Maryland-Delaware Metropolitan Statistical Area. The region takes its name from Cape Henlopen, as does the Cape Henlopen School District and Cape Henlopen State Park. Much of the region's populated areas are found along the Delaware Bay, Rehoboth Bay and the Atlantic Ocean. Northern and western parts of the Cape Region are rural areas dominated by farmland and wetlands. The area is often referred to as the Delaware Beaches.

Sussex County is located in the southern part of the U.S. state of Delaware, on the Delmarva Peninsula. As of the 2020 census, the population was 237,378, making it the state's second most populated county only behind New Castle and ahead of Kent. The county seat is Georgetown.