Cape Town International Airport is the primary international airport serving the city of Cape Town, and is the second-busiest airport in South Africa and fifth-busiest in Africa. Located approximately 20 kilometres (12 mi) from the city center, the airport was opened in 1954 to replace Cape Town's previous airport, Wingfield Aerodrome. Cape Town International Airport is the only airport in the Cape Town metropolitan area that offers scheduled passenger services. The airport has domestic and international terminals, linked by a common central terminal.

O. R. Tambo International Airport is an international airport serving the twin cities of Johannesburg and the main capital of South Africa, Pretoria. It is situated in Kempton Park, Gauteng. It serves as the primary airport for domestic and international travel for South Africa and since 2020, it is Africa's second busiest airport, with a capacity to handle up to 28 million passengers annually. The airport serves as the hub for South African Airways. The airport handled over 21 million passengers in 2017.