Carbon Run is a tributary of Shamokin Creek in Northumberland County, Pennsylvania, in the United States. It is approximately 5.2 miles (8.4 km) long and flows through Zerbe Township, Coal Township, and Shamokin. The watershed of the stream has an area of 8.78 square miles (22.7 km2). Carbon Run is impaired due to metals from acid mine drainage, which colors the stream orange. Metals such as manganese, iron, aluminum, and others occur within its water. The watershed of the stream is in the Coal Region of Pennsylvania. Much of the area in the vicinity of the stream consists of spoil piles and abandoned mining land.

Shamokin Creek is a tributary of the Susquehanna River in Northumberland County, Pennsylvania, in the United States. It is approximately 32.4 miles (52.1 km) long and flows through Mount Carmel, Mount Carmel Township, Coal Township, Shamokin, Ralpho Township, Shamokin Township, Snydertown, Upper Augusta Township, and Sunbury. The watershed of the creek has an area of 137 square miles (350 km2). It experiences significant impacts by abandoned mine drainage and many abandoned mine drainage discharges are in its watershed. Various other impairments also affect parts of the creek's watershed. Shamokin Creek is in the Appalachian Mountains section of the Ridge and Valley physiographic province. Rock formations consisting of sandstone, shale, and anthracite deposits occur in the watershed.