Carbonic anhydrase
Videos
The carbonic anhydrases form a family of enzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid. The active site of most carbonic anhydras
Active site of CAII enzyme (PDB code: 1CA2) which O = red, N = blue, Zn = grey and C = green
CAII enzyme (PDB code: 1CA2) showing the secondary structures and the hydrophobic pocket (right side of the Zn2+) formed by the beta sheet (blue) and the two valine and one tryptophan side chains
This image shows the ligands and pocket style of carbonic anhydrase.
Metalloprotein
Videos
Metalloprotein is a generic term for a protein that contains a metal ion cofactor. A large proportion of all proteins are part of this category. For instance, at least 1000 human proteins contain zinc
Carbonic anhydrase
…carbonic acid (i.e. bicarbonate and hydrogen ions). The active site of most carbonic anhydrases contains a zinc ion. They are therefore classified as metalloenzymes. The enzyme maintains acid-base balance and helps transport carbon dioxide. Carbonic anhydrase helps maintain acid–base homeostasis and regulate pH and…
EF-hand motif