The Cardinal is a long-distance passenger train operated by Amtrak between New York Penn Station and Chicago Union Station via Philadelphia, Washington, D.C., Charlottesville, Charleston, Huntington, Cincinnati, and Indianapolis. Along with the Capitol Limited and Lake Shore Limited, it is one of three trains linking the Northeast and Chicago. Its 1,146-mile (1,844 km) trip between New York and Chicago takes 281⁄4 hours.

The Long Distance Service Line is the division of Amtrak responsible for operating all intercity passenger train services in the United States longer than 750 miles (1,210 km). There are fifteen such routes as of 2023, serving over 300 stations in 39 states.