Cardwell is a city in southwest Dunklin County, Missouri, United States. The population was 713 at the 2010 census. The current Mayor of Cardwell is Brandon Cupp and the current aldermen are Harvey Beasley, Mike Clark, and Chuck Walls.

Dunklin County is located in the Bootheel of the U.S. state of Missouri. As of the 2020 census, the population was 28,283. The largest city and county seat is Kennett. The county was officially organized on February 14, 1845, and is named in honor of Daniel Dunklin, a Governor of Missouri who died the year before the county was organized.