Dragon C208 is the first Cargo Dragon 2 spacecraft, and the first in a line of International Space Station resupply craft which replaced the Dragon capsule, manufactured by SpaceX. The mission is contracted by NASA under the Commercial Resupply Services (CRS) program. It flew for the first time on the CRS-21 mission on 6 December 2020. This was the first flight for SpaceX under NASA's CRS Phase 2 contract awarded in January 2016. This was also the first time a Cargo Dragon was docked at the same time as a Crew Dragon spacecraft. This mission used Booster B1058.4.

SpaceX CRS-28, also known as SpX-28, is a Commercial Resupply Service mission to the International Space Station (ISS) launched on 5 June 2023. The mission was contracted by NASA and flown by SpaceX using Cargo Dragon C208. It was the eighth flight for SpaceX under NASA's CRS Phase 2.