The Carlton Centre is a 50-storey skyscraper and shopping centre located on Commissioner Street in central Johannesburg, South Africa. At 223 metres (732 ft), it was the tallest building in Africa for 46 years from its completion in 1973 until 2019. It is today the continent's fifth tallest building after The Leonardo, the Mohammed VI Tower in Morocco, the Great Mosque of Algiers Tower in Algeria and the Iconic Tower in Egypt. The foundations of the two buildings in the complex are 5 m (16 ft) in diameter and extend 15 m (49 ft) down to the bedrock, 35 m (115 ft) below street level. The building houses both offices and shops, and has over 46 per cent of the floor area below ground level.

Commissioner Street is a major one-way street (westwards) in the Central Business District of Johannesburg, South Africa. It runs from the M31 to the R41, and is indicated as the R24. The Carlton Centre, the 2nd-tallest building in Africa, is located on the street, as is the southern end of Newtown. There is little evidence of Commissioner Street's exact origin, although it is known that this street played a role in the development of Johannesburg.