The Cartier Building, also 653 Fifth Avenue, is a commercial building on the southeast corner of 52nd Street and Fifth Avenue in the Midtown Manhattan neighborhood of New York City. The building serves as the flagship store of Cartier in New York City. It consists of two conjoined residences completed in 1905: the Morton F. Plant residence at 651–653 Fifth Avenue, designed by Robert W. Gibson, and the Edward Holbrook residence at 4 East 52nd Street, designed by C. P. H. Gilbert.

52nd Street is a 1.9-mile-long (3.1 km) one-way street traveling west to east across Midtown Manhattan, New York City, United States. A short section of it was known as the city's center of jazz performance from the 1930s to the 1950s.