Caruthersville is a city in and the county seat of Pemiscot County, Missouri, United States, located along the Mississippi River in the Bootheel region of the state's far southeast. The population was 5,562, according to the 2020 census.

Pemiscot County is a county located in the southeastern corner in the Bootheel in the U.S. state of Missouri, with the Mississippi River forming its eastern border. As of the 2020 census, the population was 15,661. The largest city and county seat is Caruthersville. The county was officially organized on February 19, 1851. It is named for the local bayou, taken from the word pem-eskaw, meaning "liquid mud", in the language of the native Fox (Meskwaki) people. This has been an area of cotton plantations and later other commodity crops.