Casa Casuarina, also known as the Versace Mansion, is an American property built in 1930, renowned for being owned by and the place of the murder of the Italian fashion designer Gianni Versace; he lived there from 1992 until his death in 1997. It is located at 1116 Ocean Drive in the South Beach neighborhood of Miami Beach, Florida, in the Miami Beach Architectural District. Since 2015, it has been adapted into and operates as a luxury boutique hotel known as The Villa Casa Casuarina.

Giovanni Maria "Gianni" Versace was an Italian fashion designer, socialite and businessman. He was the founder of Versace, an international luxury-fashion house that produces accessories, fragrances, make-up, home furnishings and clothes. He also designed costumes for theatre and films. As a friend of Eric Clapton, Princess Diana, Naomi Campbell, Kate Moss, Madonna, Elton John, Tupac Shakur, Joan Collins and many other celebrities, he was one of the first designers to link fashion to the music world. He and his partner Antonio D'Amico were regulars on the international party scene. The place where he was born and raised, Reggio di Calabria, greatly influenced his career.