Casa Paoli is a historic house and biographical museum in barrio Cuarto, Ponce, Puerto Rico, in the Ponce Historic Zone. The house is significant as the birthplace of Antonio Paoli (1871–1946), a tenor who was the "first Puerto Rican to reach international recognition in the performing arts" and "one of the most outstanding opera singers of all times". The house was the childhood home of the artist and he was introduced to art and opera at this house during his formative years. In 1987, the house was turned into a museum to honor the career of Antonio Paoli. The building was listed on the U.S. National Register of Historic Places in 2009.

Cuarto is one of the 31 barrios of the municipality of Ponce, Puerto Rico. Together with Primero, Segundo, Tercero, Quinto, and Sexto, Cuarto is one of the municipality's six core urban barrios. It was created in 1878.