The Casinò di Campione is one of Italy's oldest Casinos, as well as Europe’s largest casino and the largest employer in the municipality of Campione d'Italia, an Italian exclave within Switzerland's Canton of Ticino, on the shores of Lake Lugano.

Campione d'Italia, is a comune of the Province of Como in the Lombardy region of Italy and an enclave surrounded by the Swiss canton of Ticino. It is also an exclave. At its closest, the enclave is less than one kilometre (0.6 mi) from the rest of Italy, but the intervening mountainous terrain requires a journey by road through the Swiss village of Bissone of over 14 km (9 mi) to reach the nearest Italian town, Lanzo d'Intelvi, and over 28 km (17 mi) to reach the city of Como.