Caswell County is a county in the U.S. state of North Carolina. It is located in the Piedmont Triad region of the state. At the 2020 census, the population was 22,736. Its county seat is Yanceyville.

The Piedmont Triad is a metropolitan region in the north-central part of the U.S. state of North Carolina anchored by three cities: Greensboro, Winston-Salem, and High Point. This close group of cities lies in the Piedmont geographical region of the United States and forms the basis of the Greensboro–Winston-Salem–High Point, NC Combined Statistical Area. As of 2012, the Piedmont Triad has an estimated population of 1,611,243 making it the 33rd largest combined statistical area in the United States.