The Catawba River is a major river located in the Southeastern United States. It originates in Western North Carolina and flows into South Carolina, where it later becomes known as the Wateree River. The river is approximately 220 miles (350 km) long. It rises in the Appalachian Mountains and drains into the Piedmont, where it has been impounded through a series of reservoirs for flood control and generation of hydroelectricity. The river is named after the Catawba tribe of Native Americans, which lives on its banks. In their language, they call themselves "yeh is-WAH h’reh", meaning "people of the river."

Western North Carolina is the region of North Carolina which includes the Appalachian Mountains; it is often known geographically as the state's Mountain Region. It contains the highest mountains in the Eastern United States, with 125 peaks rising to over 5,000 feet in elevation. Mount Mitchell at 6,684 feet, is the highest peak of the Appalachian Mountains and mainland eastern North America. The population of the 23 most commonly associated counties for the region, as measured by the 2020 U.S. Census, is 1,149,405. The region accounts for approximately 11% of North Carolina's total population.