Cathedral Dulce Nombre de Jesús, or in English, Sweet Name of Jesus Cathedral, is a cathedral of the Catholic Church in Caguas, Puerto Rico. It is located on the Plaza Palmer in the center of town, and next to the Colegio Católico Notre Dame Elementary. There are only five cathedrals in Puerto Rico and Cathedral Dulce Nombre de Jesús is the seat of the Diocese of Caguas. The patron saint of the church, as well as that of the city, is the Dulce Nombre de Jesús.

Caguas is a city and municipality of Puerto Rico located in the Central Mountain Range of Puerto Rico, south of San Juan and Trujillo Alto, west of Gurabo and San Lorenzo, and east of Aguas Buenas, Cidra, and Cayey. Caguas was founded in 1775. The municipality had a population of 127,244 at the 2020 census.